AbstractEnteric fever, primarily caused by Salmonella enterica serovar Typhi, remains a major global public health challenge. Accurate and rapid diagnosis is critical for effective patient management and the prevention of complications. While blood culture is the diagnostic gold standard, its utility is limited by low sensitivity, long turnaround times, and resource constraints in endemic areas. Serological assays detecting Typhoid IgG and IgM antibodies offer a rapid, accessible alternative. IgM antibodies appear early in the acute phase of infection, serving as a primary marker for active or recent disease. Conversely, IgG antibodies rise later, persisting for months to provide insights into past exposure, chronic carriage, or secondary immune responses. This article reviews the clinical application, diagnostic relevance, limitations, and operational utility of Typhoid IgG/IgM testing in contemporary enteric fever management. Keywords: Enteric fever; Typhoid IgG/IgM assay; Blood culture; Typhoid Conjugate Vaccine; Multidrug resistance; Resource-poor settings