The emergence of the Indo-Mediterranean as a strategic geopolitical construct reflects the growing integration of the Indo-Pacific and the Mediterranean through maritime connectivity, economic corridors, and strategic partnerships. Anchored by the India–Middle East–Europe Economic Corridor (IMEC), this evolving framework seeks to enhance resilient supply chains, secure critical sea lanes, and promote sustainable economic development amid intensifying great-power competition. Against this backdrop, India and the United States have increasingly aligned their strategic objectives to advance a rules-based maritime order, strengthen regional connectivity, and foster collaboration across the Gulf and Eastern Mediterranean. This paper examines the evolving India–U.S. strategic convergence in shaping the Indo-Mediterranean as a twenty-first-century strategic corridor. It argues that the Indo-Mediterranean represents a natural extension of the Indo-Pacific strategic vision, where maritime security, infrastructure development, digital connectivity, energy security, and technological cooperation are becoming central pillars of bilateral engagement. The study analyses how both countries leverage complementary capabilities through initiatives such as IMEC, maritime domain awareness, critical and emerging technologies, and partnerships with regional stakeholders to build a secure, resilient, and interconnected geopolitical space. Employing a qualitative methodology based on policy documents, strategic frameworks, official statements, and secondary literature, the paper evaluates the opportunities and challenges confronting this emerging strategic architecture. It further assesses the implications of regional instability, maritime chokepoints, geopolitical competition, and competing connectivity initiatives on the viability of the Indo-Mediterranean corridor. The paper concludes that sustained India–U.S. strategic cooperation has the potential to transform the Indo-Mediterranean into a cornerstone of the emerging multipolar order by fostering secure connectivity, economic resilience, and cooperative maritime governance. In doing so, the study contributes to the growing scholarly discourse on the evolving geostrategic linkages between the Indo-Pacific and the Mediterranean and their implications for regional and global security. Keywords: Indo-Mediterranean, Indo-Pacific, India–United States Relations, IMEC, Strategic Connectivity, Maritime Security, Maritime Governance, Supply Chain Resilience, Great Power Competition, Multipolar Order.